Search on: BASES, MANNICH 
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Descriptor English:   Mannich Bases 
Descriptor Spanish:   Bases de Mannich 
Descriptor Portuguese:   Bases de Mannich 
Synonyms English:   Bases, Mannich  
Tree Number:   D02.092.650
D02.522.650
Definition English:   Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols. 
Indexing Annotation English:   IM general only
History Note English:   91(77); was see under AMINES 1977-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   8524 
Unique Identifier:   D008352 

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